Grunstein and Hogness method also referred to as colony hybridization or nucleic acid hybridization is a technique primarily used in molecular biology or biotechnology to screen the colony(s) from sample site. This procedure is performed in order to
1.Minimize the costly and time consuming procedures of colony pcr technique for screening of a bacterial colony.
Main theme of this procedure is the collection of the bacterial colony from sample site and then grown on nutrient media. After growth the cultures are then transferred to matrix like nitrocellulose membrane and then binding to a radioactivally labelled complementary DNA/RNA probes.